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The bipolar disorder and diabetes

Metabolic syndrome is a set of conditions, including resistance to insulin, which can often lead to a diagnosis of diabetes type 2 if it is not reversed with diet and exercise. But sometimes factors beyond our control may cause metabolic syndrome.

Bipolar disorder is a disease whose symptoms include extremes of mood, known as depression and mania. Many drugs prescribed for bipolar disorder can place people at risk of developing metabolic syndrome.

According to the journal online, bipolar disorders:

"The prevalence of metabolic syndrome in patients with bipolar disorder is alarming, as for the general population." "The prevalence of obesity is still higher than the prevalence already very high which was estimated for the general population of the United States".

Many drugs used to manage bipolar disorder seem to contribute to the risk of developing metabolic syndrome and type 2 diabetes. Step of all medicines used in bipolar disorder cause metabolic symptoms, but the drugs listed here are more prone to causing weight gain, resistance to insulin, Hyperglycemia (high blood glucose levels) and other signs associated with the metabolic syndrome.

Olanzapine (Zyprexa) - gain of weight, hyperglycemiaSodium valproate and valproic acid (Depakote) - weight gainClozapine (clozaril) - weight gain, hyperglycemiaQuetiapine (Seroquel) - weight gain, hyperglycemiaRisperidone (Risperdal) - weight gain, hyperglycemiaLithium - transient hyperglycemia

Many physicians have become aware of the consequences of bipolar disorder and drug accompanying it on the development of the metabolic syndrome and diabetes. According to the journal online, Times psychiatric, January 2007:

"In view of the emerging recognition of the true enormity of metabolic consequences of bipolar disorder, drugs with a beneficial metabolic profile should be considered first-line treatment in the management in the long term for this condition."

In other words, drugs that cause the symptoms of the metabolic syndrome must be prescribed first. Only if these drugs are ineffective in the treatment of bipolar disorder, and then must the drugs that are likely to cause metabolic syndrome be prescribed. Also if the patients on the drugs, they should be monitored for the gain of weight, high strength of cholesterol and insulin and glucose intolerance.

Sources:

Kelly, William j. (Ed.). (2007) In nursing 2007 Drug Handbook (27th ed.), Ambler, PA: Lippincott, Williams and Wilkins.

Antipsychotic drugs raise obesity, diabetes and cardiovascular disease risk. Retrieved January 8, 2008, the American Diabetes Association Web site: http://www.diabetes.org/for-media/2004-press-releases/jan-27-04.jsp

Fagiolini, Andrea, Frank, Ellen, Scott, John a., Turkin, Scott & Kupfer, David j. (2005). Metabolic syndrome in bipolar disorder: findings from the Centre of bipolar disorder for Pennsylvanians. Bipolar disorders. 7, 424-430.

Of Mello, MD, Dale a., Narang, MD, Supriya & Agredano, MD, Gina (2007). Prevalence and consequences of the Metabolic Syndrome in bipolar disorder. Psychiatric times. Vol. 24.

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